Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Biometrics and Information Science, R&D China, AstraZeneca, Guangzhou, China
Dr. Zhuqing Yu is currently working in Department of Biometrics and Information Science, R&D China, AstraZeneca, Guangzhou, China. He has published numerous research papers and articles in reputed journals and has various other achievements in the related studies. He has extended his valuable service towards the scientific community with his extensive research work.
Research Article
Investigating Synthetic Controls with Randomized Clinical Trial Data in Rheumatoid Arthritis Studies
Author(s): Zailong Wang*, Zhuqing Yu, Su Chen and Lanju Zhang
The cost of clinical research for new drug development has been increasing rapidly. An effective approach to reduce
the cost of clinical trials is to use a synthetic control arm to substitute a concurrent control arm. Synthetic control
arms are usually created with propensity-score-based methods from historical or external patient-level control data.
Although there is much literature discussing how to create synthetic control arms, little is known about how synthetic
control arms perform compared to concurrent control arms in real clinical trials. In this paper, we take a real
randomized controlled clinical trial and create a synthetic control arm for it using propensity-score-based methods
from the control data in other randomized clinical trials. The goal is to demonstrate validity of using synthetic
control arms by comparing the performance of synthetic control.. View More»
DOI:
10.35248/2167-0870.21.11.466