Journal of Clinical Trials

Journal of Clinical Trials
Open Access

ISSN: 2167-0870

+44 20 3868 9735

Yuanqiao Ma

Department of Cell Signal Transduction, Medical School of Henan University, Henan, China

  • Research Article   
    Prognostic Analysis of PTEN Mutation in Endometrial Carcinoma
    Author(s): Chaopeng Ye, Yuanqiao Ma, Qi Zhang, Wei Zhao* and Guoqing li

    Purpose: Endometrial Carcinoma (EC) is recognized as one of the most common female reproductive system malignant tumors. Great efforts have been made to improve the diagnosis and prognostic analysis of EC, however, more sensitive prognostic evaluation system for EC remains to be established. The mutation status of PTEN and its association with clinical characteristics, as well as its prognostic value in EC need to be evaluated. Methods: TCGA dataset comprised of 526 EC cases were used to perform a comprehensive analysis of PTEN mutation. Kaplan-Meier survival plot were performed to analyze the clinical significance of PTEN mutation. GO, KEGG pathway and IPA network analysis were performed to identify the specific pathways for PTEN mutation patients. And the prognostic value of PTEN mutation was further analyzed. .. Read More»
    DOI: 10.35248/2167-0870.22.S17.002

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