Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Laboratory Medicine, Guangxi Medical University, Nanning, Guangxi, China
Research Article
Platelets Promote Metastasis of Hepatocellular Carcinoma Cells through Wnt-?- Catenin Signaling Pathway
Author(s): Xue Qin*, Junhui Huang, Yaocan Liang, Huaping Chen, Zuojian Hu, Donghua Zhang, Xuelian Ruan, Fangfyi Wei, Jiyu Meng and Lishai Mo
Increasing evidence suggests that platelets play a critical role in tumor development but the mechanism of platelet tumor interactions is not clear.
This study aims to investigate the effect of platelet tumor cell interactions on Hepatocellular Carcinoma ( HCC) metastasis. The results showed that the invasive migration ability of Huh7 was significantly enhanced after coincubation of cells with platelets derived from HCC patients and healthy controls. Moreover, the apoptosis of Huh 7 was reduced after co-incubation. In addition, the expression of Wnt-β-catenin related proteins was elevated after coincubation. Therefore, we suggest that platelets promote the growth and metastasis of HCC cells through βW- ntcatenin signaling pathway... View More»
DOI:
10.35248/JCCLM.23.6.270