Journal of Clinical Trials
Open Access

Department of Laboratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China

Publications

• Research Article   
  Biomarkers and Targets Identification among CXC Chemokines in the Colon Adenocarcinoma
  Author(s): Heng Wang, Changqing Guo, Jun Luo, Quan Li, Buqing Fubuqing* and Wei Jiang
  
  Background: COAD is among the most prevalent malignancy, with a very high incidence rate. Crosstalk between cancer and interstitial cells significantly affects cancer development, modulated partly by chemokines production. When present in the tumor microenvironment, CXC chemokines have been shown to regulate tumor cell activity and influence immune cell transport, resulting in anti-tumor immune mechanisms and influencing the outcomes of the patient; nonetheless, the CXC chemokines expression levels in COAD, as well as their prognostic significance, have not yet been established. Methods: This study used UALCAN, GeneMANIA, STRING, TRRUST, cBioPortal, TIMER, and GEPIA. Results: The expression of CXC1/2/3/5/6/11/12/13/14/16/17 in COAD patients was shown to be significantly correlated with the pathological s.. View More»
  DOI: 10.35248/2167-0870.22.12.500

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