Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
ISSN: 2167-0412
Department of Pharmacy, Norwegian Centre for Mental Disorders Research, University of Oslo, Norway
Research Article
Musa paradisiaca L. May Restore Pancreatic Morphology and Function to Trigger its Anti-Diabetic and Hypolipidemic Activities in Alloxon-Induce Diabetic Rats
Author(s): Khizar A, Rizwania GH, Zahida H, Shareef H and Taqi MM*
Prevalence of diabetes mellitus is on steady rise, though several therapeutic options are available to treat diabetes mellitus. Medicinal plants are in use alongside prescribed therapies; however more research on medicinal plants is warranted to retrieve their anti-diabetic mechanisms to develop low cost, safe and effective anti-diabetic drugs. Aim of current study is to (a) determine antidiabetic and hypolipidemic potential of organic extract of Musa paradisiaca L. (b) to retrieve underlying mechanisms responsible for anti-diabetic effects triggered by the plant. Alloxan was used to induce diabetes mellitus in rates. Two standard drugs (Glibenclamide 2.5 mg/kg, insulin 4 U/200 mg/dl blood glucose) and various doses of organic plant extract from different morphological parts (100 mg/kg, 250 mg/kg and 500 mg/kg) were administered orally to the groups of healthy and diabetic ra.. View More»
DOI:
10.35248/2167-0412.19.8.333