Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
ISSN: 2167-0412
Department of Pharmaceutical sciences, Institute of Pharmaceutical sciences, Jinnah Sindh Medical University, 75510, Karachi, Pakistan
Research Article
Musa paradisiaca L. May Restore Pancreatic Morphology and Function to Trigger its Anti-Diabetic and Hypolipidemic Activities in Alloxon-Induce Diabetic Rats
Author(s): Khizar A, Rizwania GH, Zahida H, Shareef H and Taqi MM*
Prevalence of diabetes mellitus is on steady rise, though several therapeutic options are available to treat diabetes mellitus. Medicinal plants are in use alongside prescribed therapies; however more research on medicinal plants is warranted to retrieve their anti-diabetic mechanisms to develop low cost, safe and effective anti-diabetic drugs. Aim of current study is to (a) determine antidiabetic and hypolipidemic potential of organic extract of Musa paradisiaca L. (b) to retrieve underlying mechanisms responsible for anti-diabetic effects triggered by the plant. Alloxan was used to induce diabetes mellitus in rates. Two standard drugs (Glibenclamide 2.5 mg/kg, insulin 4 U/200 mg/dl blood glucose) and various doses of organic plant extract from different morphological parts (100 mg/kg, 250 mg/kg and 500 mg/kg) were administered orally to the groups of healthy and diabetic ra.. View More»
DOI:
10.35248/2167-0412.19.8.333