Journal of Clinical Chemistry and Laboratory Medicine

Journal of Clinical Chemistry and Laboratory Medicine
Open Access

ISSN: 2736-6588

+44 1223 790975

Suman Thummanagoti

Department of Applied Chemistry, Laboratory of Combinatorial Drug Discovery, National Chiao Tung University, Hsinchu, Taiwan

  • Research Article   
    Microwave Assisted Soluble Polymer Supported Synthesis of 7-(1HBenzoimmidazol-2-yl)-10H-benzo[4,5]imidazo[1,2-a][1,3,5]triazine-2,4-dione
    Author(s): Chung-Ming Sun* and Suman Thummanagoti

    Soluble polymer supported bisheterocycles has been synthesized using a convergent synthesis under microwave assisted synthesis. All sequential steps carried out 7-(1H-Benzoimmidazol-2-yl)10H benzo-4,5-imidazo-1,2-a 1,3,5- triazine-2,4-dione monitored by the spectroscopic analytical data reported. 4-fluro-3-nitrobenzoicacid with various amines nucleophilic substitutions subsequent reduction followed by the acid functional repeated unit of 4 fluro-3- nitro benzoicacid heterocyclization lead to the bisheterocyclic scaffold further sequential transformation of nucleophilic substitution with fluoro functional group with various amines followed by reduction of nitro to the amine; to the terminal diamine using cyanobromide leaves bisbenzimidazole with an amine; all steps carried out sing the polymerethleneglycol as support under microwave irradiations all steps compared .. View More»
    DOI: 10.35248/jcclm.21.4.191

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