Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
+44 1223 790975
ISSN: 2736-6588
+44 1223 790975
Chung-Ming Sun* and Suman Thummanagoti
Soluble polymer supported bisheterocycles has been synthesized using a convergent synthesis under microwave assisted synthesis. All sequential steps carried out 7-(1H-Benzoimmidazol-2-yl)10H benzo-4,5-imidazo-1,2-a 1,3,5- triazine-2,4-dione monitored by the spectroscopic analytical data reported. 4-fluro-3-nitrobenzoicacid with various amines nucleophilic substitutions subsequent reduction followed by the acid functional repeated unit of 4 fluro-3- nitro benzoicacid heterocyclization lead to the bisheterocyclic scaffold further sequential transformation of nucleophilic substitution with fluoro functional group with various amines followed by reduction of nitro to the amine; to the terminal diamine using cyanobromide leaves bisbenzimidazole with an amine; all steps carried out sing the polymerethleneglycol as support under microwave irradiations all steps compared and analytical spectroscopic data produced. Further under basic conditions bisheteroamine under microwave reaction condition with cloroacetylesters and chloroacetylisocyanates reacts to diamines of benzimidazole with 7-(1H-Benzoimmidazol-2- yl)10H benzo-4,5-imidazo-1,2-a 1,3,5-triazine-2,4-dione. Further under KCN methanol polymer support leaves to molecular scaffolds. A microwave-promoted three-component one pot reaction has been developed to provide access the core 7 (1H Benzoimmidazol-2-yl) 10H benzo-4,5-imidazo-1,2a-1,3,5 triazine-2,4-dione scaffold, which is common to several families of alkaloids with significant biological activities.
Published Date: 2021-10-25; Received Date: 2021-10-04