Journal of Probiotics & Health
Open Access
ISSN: 2329-8901
ISSN: 2329-8901
Department of Medicine, University of Banja Luka, Bosnia and Herzegovina
Research Article
Probiotic Treatment does not Change Sulphasalazineand its Metabolites Excretion in Patients with Inflammatory Bowel Disease
Author(s): Natasa Stojakovic*, Momir Mikov, Stevan Trbojevic, Sasa Vukmirovic, Ranko Skrbic and Svjetlana Stoisavljevic Satara
Background: The manipulation of gut microflora composition and activity by probiotics could modify the enzymatic activity of intestinal bacteria. In this study, we sought to investigate the influence of probiotic treatment on sulphasalazine (SSZ) excretion in inflammatory bowel disease (IBD) patients.
Methods: Newly diagnosed IBD patients were randomised in two groups; half of subjects were treated with SSZ and other half were treated with combination of SSZ and probiotics. At the each visit, patients were assesed clinically andfecal samples and total volume of 24 h urine was measured and noted. Urine samples were collected and analized by liquid chromatography-mass spectrometry/mass spectrometryfor determination of SSZ and its metabolites. The enzymatic activity of azoreductase by intestinal bacteria in the fecal contents was determined spe.. View More»