Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Cardiology, Cardiology Research Institute, Tomsk, Russian Federation
Research Article
Intracoronary Administration of Epinephrine and Verapamil in the Refractory No-Reflow Phenomenon in Patients with Acute Myocardial Infarction: Study Protocol for an Open-Label Randomized Controlled Trial
Author(s): Stanislav V Dil*, Vyacheslav V Ryabov and Evgeny V Vyshlov
Background: Refractory no-reflow syndrome can still occur, negating many of the benefits of restoring culprit vessel
patency, and is associated with a worse in-hospital and long-term prognosis. Epinephrine may at lower doses exert
potent beta receptor agonist properties that mediate coronary vasodilatation. The trial aims to estimate the efficacy
and safety of the administration of intracoronary adrenalin, verapamil, as well as their combination versus standard
treatment in patients with STEMI and refractory coronary no-reflow.
Methods/Design: Consecutive patients with STEMI and refractory no-reflow syndrome will be randomized into 4
groups: Standard therapy only, intracoronary administration of epinephrine, verapamil, epinephrine+verapamil. All
patients will undergo an assessment of epicardial blood flow using TIMI score, pe.. View More»
DOI:
10.35248/2167-0870.23.13.527