Pediatrics & Therapeutics

Pediatrics & Therapeutics
Open Access

ISSN: 2161-0665

+44 1478 350008

Srinivas Ramakrishnan

Department of Neonatal Intensive Care Unit, Kovai Medical Center and Hospital, Coimbatore, Tamil Nadu, India

  • Case Report   
    Diazoxide Unresponsive Congenital Hyperinsulinism in Neonates: A Case Report
    Author(s): Gayathiri Govindaraju, Srinivas Ramakrishnan* and Balakrishnan Rajaiah

    Glucose is the prime energy source for brain and other vital organs of the body. Congenital hyperinsulinisms occur due to dysregulated insulin secretion. Persistent hypoglycemia can cause irreversible damage to neurons. Patients with Hyperinsulinemic Hypoglycemia (HH) present in first 24-48 hours of life in newborn period with non-specific symptoms of hypoglycemia as lethargy, poor feeding, high pitched and irritable cry, apnea, jitteriness, exaggerated reflexes, seizure and coma. Cornerstone of clinical management involves early diagnosis and appropriate therapy for all forms of HH. Analysis of blood sample, collected during hypoglycemia for intermediary metabolites and hormones is critical for diagnosis and management of hypoglycemia in neonates. Managing patients with persistent and prolonged hypoglycemia will require frequent blood glucose monitoring and central venous access for .. View More»
    DOI: 10.35248/ 2161-0665.22.12.402

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