Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Medicine and Surgery University of Perugia, P.le L. Severi 1, 06132, Perugia, Italy
Original Research Article
Genomic Profiling in Anaplastic and Poorly Differentiated Thyroid
Carcinomas: A Preliminary Study
Author(s): Anna Dellai*, Alessandro Scandurra, Sonia Moretti, Martina Mandarano, Angelo Sidoni, Efisio Puxeddu, Cristina Kullmann, Maurizio Ferrari, Cristina Lapucci and Marcello Gambacorta
Objective: Poorly Differentiated Thyroid Carcinomas (PDTC) and Anaplastic Thyroid Carcinoma (ATC) are different subtypes of thyroid carcinoma characterized respectively by a medium to high degree of dedifferentiation. These rare tumor types account for the majority of deaths from thyroid cancer, having usually a poor prognosis and short life expectancy. Diagnosis is not always straightforward due to the high degree of dedifferentiation of these tumors. Affected patients, on the other side, need for quick and targeted clinical answers for an effective treatment. Recent studies utilizing next generation sequencing have brought light into the molecular landscape of these tumors, providing evidences to support a stepwise progression from differentiated thyroid carcinomas to anaplastic thyroid carcinomas.
Methods: We tes.. View More»
DOI:
10.35248/JCCLM.22.05.226