Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Oncology, Cancer of the Reference Center for Women's Health (CRSM) Perola Byington Hospital, Sao Paulo, Brazil
Research Article
Differential Behavior of Bone Turnover Markers in Women with Bone Metastatic Breast Cancer or Osteoporosis
Author(s): Ana Laura Soares*, Jose Gilberto Henrique Vieira, Linda Denise Fernandes Moreira, Andre Goncalves da Silva, Marise Lazaretti Castro, Sergio Daniel Simon, Luiz Henrique Gebrim and Afonso Celso Pinto Nazario
Background: This study was designed to describe Bone Turnover Marker (BTM) profiles in women.
Patients and methods: In all, 197 patients (age 61 (36-90) years) comprising five groups were studied: Osteoporosis with (OPBP+) or without (OPBP-) bisphosphonate use; bone metastatic breast cancer with (BMBP+) or without (BMBP-) BP use; and healthy controls without BP (CBP-) use. Procollagen type 1 amino-terminal Propeptide (P1NP) and Carboxy-terminal Telopeptideof type 1 collagen (CTX) wereanalyzed.
Results: The medians (25%-75%; ng/mL) for P1NP were as follows: BMBP (236.95(165.0-328.0))> CBP(47.25(33.5-63.7))=OPBP-(50.9(37.4-63.9))>BMBP+(26.9(11.8-46.3))=OPB+(19.5(12.6-27.3)). The medians (25%-75%; ng/mL) for CTX wereas follows: BMBP-(0.567(0.457-0.803))=OPBP-(0.360(0.318-0.650))>CBP-(0.297(0.203-0.402))>BM.. View More»
DOI:
10.35248/2167-0870.23.13.271