Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Department of Ophthalmology, The Second of Xiangya Hospital, Central South University, Changsha, China
Review Article
The Role of PI3K Isoforms in Ocular Angiogenesis
Author(s): Dongwei Lai, Baiqi Liu, Linqing Xiong, Yiwei Yin, Xiaobo Xia and Wenyi Wu*
Ocular angiogenesis is an important contributor to many vision-decreasing diseases, such as retinopathy of prematurity,
proliferative diabetic retinopathy, as well as age-related macular degeneration. Understanding the molecular mechanism
of angiogenesis has advanced the development of effective medicine in preventing ocular neovascularization.
Phosphoinositide 3 kinases (PI3Ks), a main downstream of growth factors, are a family of lipases that are evolutionarily
conserved in their ability to regulate cell growth and survival as well as migration and metabolism. Much evidence
showed that it also plays a significant role in angiogenesis. Here, we review the distinct functions of class I PI3Ks in
the canonical angiogenic pathway and its potential mechanism as a novel therapeutic target in ocular pathological
angiogenesis... View More»
DOI:
10.35248/2155-9570.23.14.955