Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Department of Immunochemistry-Immunology, Institute of Hematology and Immunology, Havana, Cuba
Research Article
Immunomodulatory Effect of Biomodulin T® on B1a Lymphocytes in Older Cuban Adults
Author(s): Vianed Marsan Suarez*, Imilla Casado Hernandez, Elizabeth Hernandez Ramos, Yenisey Triana Marrero, Yaneisy Duarte Perez, Mibelys Santana Garcia, Lazaro Yendry Nunez Rodriguez, Eduardo Alfonso Hernandez Marsan, Alexis Labrada Rosado and Consuelo Macias Abraham
Introduction: B1a lymphocytes constitute components of the innate immune response. They maintain their existence by self-renewal of preexisting cells, a process that declines with age.
Objective: Determine the effect induced by Biomodulin T® (BT) on B1a lymphocytes in older Cuban adults.
Methods: 30 older adults were studied. The included subjects received 1 bulb of BT intramuscularly, twice a week, for six weeks. The subpopulations of B1a lymphocytes CD19+CD5+, CD20+CD5+ and CD19+CD20 were determined. Descriptive statistics were evaluated: Median, Standard Deviation (SD) and Odds Ratios (OR) after six weeks and six months after completing the course.
Results: The median percentages and absolute counts of B1a CD5+CD20.. View More»
DOI:
10.35248/2155-9899.25.16.753