Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Vianed Marsan Suarez*, Imilla Casado Hernandez, Elizabeth Hernandez Ramos, Yenisey Triana Marrero, Yaneisy Duarte Perez, Mibelys Santana Garcia, Lazaro Yendry Nunez Rodriguez, Eduardo Alfonso Hernandez Marsan, Alexis Labrada Rosado and Consuelo Macias Abraham
Introduction: B1a lymphocytes constitute components of the innate immune response. They maintain their existence by self-renewal of preexisting cells, a process that declines with age.
Objective: Determine the effect induced by Biomodulin T® (BT) on B1a lymphocytes in older Cuban adults.
Methods: 30 older adults were studied. The included subjects received 1 bulb of BT intramuscularly, twice a week, for six weeks. The subpopulations of B1a lymphocytes CD19+CD5+, CD20+CD5+ and CD19+CD20 were determined. Descriptive statistics were evaluated: Median, Standard Deviation (SD) and Odds Ratios (OR) after six weeks and six months after completing the course.
Results: The median percentages and absolute counts of B1a CD5+CD20+ lymphocytes increased after 6 weeks of treatment with BT (0.955 vs. 2.110, SD 6.017 vs. 2.380) and (17.02 vs. 40.58, SD 80.09 vs. 39.70), with significance statistics, p=0.026 and p=0.014, respectively. The percentage and absolute count of lymphocytes that coexpressed CD19+ and CD20+ antigens decreased after 6 weeks of treatment with BT with statistical significance, p=0.014 and p=0.08, respectively. At 6 months after completing the treatment, both the percentage and the absolute count of them continued to increase with statistical significance, p=0.012 and p=0.011, respectively.
Conclusion: BT has an immunomodulatory effect on B1a CD19+CD20+ and CD5+CD20+ lymphocytes in older Cuban adults during 6 weeks of treatment.
Published Date: 2025-03-12; Received Date: 2024-05-13