Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Vianed Marsan Suarez*, Imilla Casado Hernandez, Elizabeth Hernandez Ramos, Yenisey Triana Marrero, Yaneisy Duarte Perez, Mibelys Santana Garcia, Lazaro Yendry Nunez Rodriguez, Eduardo Alfonso Hernandez Marsan, Alexis Labrada Rosado, Consuelo Macias Abraham
Introduction: B1a lymphocytes constitute components of the innate immune response. They maintain their existence by self-renewal of preexisting cells, a process that declines with age.
Objective: Determine the effect induced by Biomodulin T® (BT) on B1a lymphocytes in older Cuban adults. Methods: 30 older adults were studied. The included subjects received 1 bulb of BT intramuscularly, twice a week, for six weeks. The subpopulations of B1a lymphocytes CD19+CD5+, CD20+CD5+ and CD19+CD20 were determined. Descriptive statistics were evaluated: Median, Standard Deviation (SD) and Odds Ratios (OR) after six weeks and six months after completing the course.
Results: The median percentages and absolute counts of B1a CD5+CD20+ lymphocytes increased after 6 weeks of treatment with BT (0.955 vs. 2.110, SD 6.017 vs. 2.380) and (17.02 vs. 40.58, SD 80.09 vs. 39.70), with significance statistics, p=0.026 and p=0.014, respectively. The percentage and absolute count of lymphocytes that coexpressed CD19+ and CD20+ antigens decreased after 6 weeks of treatment with BT with statistical significance, p=0.014 and p=0.08, respectively. At 6 months after completing the treatment, both the percentage and the absolute count of them continued to increase with statistical significance, p=0.012 and p=0.011, respectively.
Conclusion: BT has an immunomodulatory effect on B1a CD19+CD20+ and CD5+CD20+ lymphocytes in older Cuban adults during 6 weeks of treatment.
Published Date: 2025-03-12; Received Date: 2024-05-13