Journal of Probiotics & Health
Open Access
ISSN: 2329-8901
+44 1223 790975
ISSN: 2329-8901
+44 1223 790975
Vizera, d.o.o., Vojkova 4, 1000 Ljubljana, Slovenia
Research Article
Effect of Daily Bacillus subtilis DE111 Intake on Gastrointestinal
Health and Respiratory Infections in Children Attending Day-care: A
Randomised, Parallel, Double-blind, Placebo-controlled Study
Author(s): Mizuho Matevž Slivnik, Katarina Črnigoj Kristan, Nanča �?ebron Lipovec, Igor Locatelli, Rok Orel and Alison M Winger*
Children beginning preschool typically have an increased prevalence of gastrointestinal and respiratory infections. This study aimed to evaluate safety and efficacy of the probiotic Bacillus subtilis DE111® in gastrointestinal health and respiratory infections in preschool children. In a randomised, parallel, double-blind placebo-controlled study 102 day-care attending children aged 2-6 years received B. subtilis DE111® (1 × 109 CFU) or placebo once a day for 8 weeks. Participant diaries were completed by parents and evaluated by investigators to follow the incidence and duration of indicators of gastrointestinal health and respiratory infections as well as any adverse events. Saliva samples were collected at baseline and completion of the intervention to measure sIgA levels. A significant reduction in duration of vomiting (2 days vs. 14 days, p=0.045), duration of hard .. View More»
DOI:
10.35248/2329-8901.20.8:225