Journal of Clinical Trials
Open Access

Department of Inhalation Research, Korea Institute of Toxicology, 30 Baehak 1-gil, Jeonguep, Jeollabuk-do, 56212, Republic of Korea

Publications

• Review Article   
  Update on the Two Contrasting Immunotoxic Effects of Formaldehyde Inhalation
  Author(s): Jeongsik Park and Jeong Ho Hwang*
  
  Formaldehyde (FA) is a colorless, flammable, and highly reactive one-carbon compound that is emitted from several objects at homes and workplaces. FA is also widely found in many products used in medical colleges, hospitals, and factories. Many people are exposed to FA daily via inhalation at their homes and workplaces, which contributes to environmental and occupational health problems and potentially, cancer hazards. Two types of immunomodulatory effects of FA have been widely reported. On the one hand, FA inhalation and exposure induces or exacerbates eosinophilic airway inflammation with increased bronchial hyperresponsiveness and Th2-related cytokine secretion, resulting in Th2-type immune diseases such as allergic asthma and dermatitis. On the other hand, FA exposure has no significant deleterious effect on respiratory distress and instead prevents allergic lung inflammation by .. View More»
  DOI: 10.35248/2167-0870.22.11.494

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