Pediatrics & Therapeutics
Open Access
ISSN: 2161-0665
ISSN: 2161-0665
Department of Biochemistry, University of Ilorin, Ilorin, Nigeria
Research Article
Malaria Diagnostic and Parasite Density Prediction Potentials of Some Serum Biochemical Parameters in Children with Severe Falciparum Malaria Treated with Artesunate/Artemether-Lumefantrine Combination Therapy
Author(s): Okoli C.A, Igunnu A, Adebayo J.O*, Oguche S and Malomo S.O
Prompt and accurate diagnosis and parasite density quantification are keys to effective malaria treatment. The malaria
diagnostic and parasite density quantification methods currently in use are not without their shortcomings. Thus,
there is the need for new methods with high sensitivity, specificity and predictive values that may complement other
methods in use. In this study, 100 children (1 years-10 years) diagnosed of severe malaria were treated with 2.4 mg/kg
body weight of artesunate intravenously at 0 hour and then 1.2 mg/kg body weight at 12 hours, 24 hours and 48
hours, followed by artemether-lumefantrine combination therapy at doses of 4 mg/kg body weight of artemether and
24 mg/kg body weight of lumefantrine for three days, with 200 clinically healthy children of the same age range
serving as control. The diagnostic potential of selected biochemical par.. View More»
DOI:
10.35841/2161-0665.23.13.515