Translational Medicine
Open Access
ISSN: 2161-1025
ISSN: 2161-1025
Department of Biotechnology and Biochemistry, Vidyasagar University, West Bengal, India
Research Article
Current Exosomes Research in Cellular Physiology, Disease diagnostics and Therapeutic Biomolecules Delivery
Author(s): Asit Kumar Chakraborty*
Lipid molecules form spherical micilles in water environment and can entrap biomolecules easily. Phospholipids and cholesterol are main components of our cell membrane. Phospholipids have two long (C12-22) chain fatty acids with hydrophobic nature making ester bonds with glycerol and the 3rd –OH of glycerol connected to a highly charged phosphate group followed by choline or ethanolamine or sugars. Synthetic phospholipid vacuoles or liposomes entrapped transgenes and can transfer biomolecules into nucleus for transcription and further expression in the ribosome. Such gene transfer technologies in human cells were easy and non-toxic delivery of therapeutic genes into nucleus of target organ corrected the defect gene with improvement of health conditions. Such lipid extracellular vehicles or exosomes (20 nm-200 nm) were also produced naturally from membrane of stress-induced proka.. View More»
DOI:
10.35248/2161-1025.25.15.339