Journal of Chromatography & Separation Techniques
Open Access
ISSN: 2157-7064
ISSN: 2157-7064
Department of forensic science and criminology, Abu Dhabi police, Abu Dhabi, UAE
Research Article
Simultaneous Quantitative Determination of Synthetic Cathinone Enantiomers in Urine by GC-NCI-MS/MS using Menthylchloroformate as Chiral Derivatization Reagent
Author(s): Meetani MA*, Alzaabi JA, Hisaindee S, Altabaji MK and Alremeithi R
Development and validation of a new analytical method for enantioseparation and quantitation of synthetic
cathinones is reported using a chiral derivatization agent (CDA) and GC-MS triple quadrupole mass spectrometry
with negative chemical ionization (NCI) mode. Indirect separation of ten synthetic cathinone compounds has been achieved using a commercially available optically pure CDA called (1R)-(-)-menthylchloroformate (MCF). MCF was capable of converting synthetic cathinone enantiomers into diastereoisomers, which were later separated with good
resolution on an ultra-inert 60 m achiral stationary phase column. An internal standard (IS), 3-methylmethcathinone
(3-MMC) was used for quantitation of synthetic cathinone diastereoisomers. Method validation in terms of
calibration curve linearity, sensitivity in terms of limits of detections (LODs), limits of quantitation (.. View More»
DOI:
10.35248/2157-7064.20.11.436