Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Gastroenterology, Mersin University, Mersin, Turkey
Research Article
Erythrocyte Sedimentation Rate and Gamma-glutamyl Transpeptidase Combined are Potent Predictors of Survival and Tumor Characteristics in
Hepatocellular Carcinoma Patients
Author(s): Brian Carr*, Akkiz H, Guerra V, Donghia R, Yalçin K, Karaogullarından U, Altıntas E, Ozakyol A, Şimşek H, Balaban HY, Balkan A, Uyanıkoglu A and Ekin N
Introduction: Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) are acute phase reactants and
Gamma-Glutamyl Transpeptidase (GGT) is a liver enzyme that is associated with prognosis in patients with
Hepatocellular Carcinoma (HCC).
Objective: To evaluate the value of ESR and GGT singly and together in HCC prognosis and as predictors of tumor
aggressiveness parameters.
Methods: The database from a large cohort of Turkish HCC patients was examined retrospectively for the prognostic
usefulness of blood ESR and GGT levels and the associated patient subgroup characteristics.
Results: Patients with low vs. high blood ESR or GGT values had greater than double survival, with Hazard Ratios
(HR) by Cox regression of 1.543 and 1.833 respectively. The combination of ESR plu.. View More»