Rheumatology: Current Research
Open Access
ISSN: 2161-1149 (Printed)
+44-20-4587-4809
ISSN: 2161-1149 (Printed)
+44-20-4587-4809
Zhuoli Zhang
MD, PhD, Director, Rheumatology and Clinical Immunology Department, Peking University First Hospital, Address: No.8, Xishiku Street West District, Beijing, 100034,
China
Mini Review
The Important Roles of C4d in Systemic Lupus Erythematosus
Author(s): Juan Li and Zhuoli ZhangJuan Li and Zhuoli Zhang
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of various autoantibodies and the injury of multiple systems. It is well known that the complement system plays an important role in the pathogenesis of SLE. Complement activation product C4d is a marker of the classical complement activation and hence can be used to reflect the tissue injury as well as therapeutic effects. Besides its important role in antibody-mediated rejection, C4d has been increasingly recognized as a potential biomarker in SLE. Here we will summarize the recent advances of C4d in SLE.
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DOI:
10.4172/2161-1149.1000135