Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Yoshinori Umezawa
3-25-8 Nishishinbashi, Minato-ku, Tokyo, 105-8461
Japan
Research Article
Algorithm for Selecting Ideal Biologic Treatment for Psoriasis
Author(s): Yoshinori Umezawa, Akihiko Asahina, Sota Kikuchi, Koichi Yanaba and Hidemi NakagawaYoshinori Umezawa, Akihiko Asahina, Sota Kikuchi, Koichi Yanaba and Hidemi Nakagawa
Biologics are the standard treatment for moderate-to-severe psoriasis due to their efficacy and safety. However, the selection of appropriate biologics is complicated by patient characteristics, treatment regimen, and cost. We constructed an algorithm to select biologics based on psoriasis type (psoriasis vulgaris or psoriasis arthritis), Psoriasis Area and Severity Index (PASI) score (≥ 20 or <20) and body mass index (≥ 25 or <25). To validate our algorithm, we retrospectively analyzed 134 patients treated with biologics. Based on the algorithm, patients were categorized into the following treatment groups: infliximab-appropriate (IFX-ap), n=33; adalimumab-appropriate (ADA-ap), n=44; and ustekinumab-appropriate (UST-ap), n=57. The relationship between each agent-appropriate group and the efficacy of each agent was analyzed. Among IFX-ap patients (n=33), the reduction in P.. View More»
DOI:
10.4172/2155-9554.1000297