Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
+44 1223 790975
ISSN: 2167-7700
+44 1223 790975
Weiwei Tang
Nanjing First Hospital,
Nanjing
Indiana
Research Article
Effects of EZH2 Polymorphisms on Susceptibility to Various Carcinomas: Evidence from 6 Publications
Author(s): Weiwei Tang, Jian Zhou, Handong Sun, Yun Hu, Jian Zhou, Yiwei Yao, Qian Wang, Hongyong Cao and Hanjin WangWeiwei Tang, Jian Zhou, Handong Sun, Yun Hu, Jian Zhou, Yiwei Yao, Qian Wang, Hongyong Cao and Hanjin Wang
Enhancer of zeste homolog2 (EZH2) is a polycomb group protein, playing a key role in epigenetic chromatin modifying, cell-cycle regulating, and has been reported associated with a variety of malignancies. Published research on EZH2 gene polymorphism and cancer risk are inconsistent, therefore, this study aimed to evaluate the association between EZH2 gene polymorphism and several types of cancer risks. Computerized literature search was carried out in the PubMed, Web of Science, EMBASE and China National Knowledge Infrastructure (CNKI) before the date of July 20, 2017. Each gene was estimated by odds ratios(ORs) and 95% confidence intervals (CIs) and I2 value was used to assess heterogeneity. Overall analysis were carried out with RevMan5.3 software. The result showed the individuals carrying at least one T allele at EZH2 .. View More»
DOI:
10.4172/2167-7700.1000252