Clinical Pediatrics: Open Access
Open Access
ISSN: 2572-0775
ISSN: 2572-0775
Wai Lin Tun
Myanmar
Research Article
Antiretroviral-therapy-related Hepatotoxicity in HIV-infected Children in Integrated HIV-care Clinic, Mandalay Childrens Hospital, Myanmar
Author(s): Wai Lin Tun, Khaing KW and Tin MWai Lin Tun, Khaing KW and Tin M
Objectives: To determine the incidence and severity of antiretroviral-therapy-related hepatotoxicity in HIV infected children in the local population and to relate hepatotoxicity with patient characteristics such as age, gender, baseline aminotransferase levels, clinical stages and immunologic categories at the initiation of antiretroviral therapy (ART) and types of ART, in the Integrated HIV-care Clinic, Mandalay Children’s Hospital, Myanmar.
Method: This study was performed on 68 HIV-infected children in 2010. They were followed up for 8 weeks from the start of ART. Serum ALT and AST levels were measured before the initiation of ART, and then again at 2 weeks, 4 weeks and 8 weeks from the start of ART. The severity of hepatotoxicity was determined by the highest level of ALT or AST during the first eight weeks. Patients with document.. View More»
DOI:
10.4172/2572-0775.1000105