Journal of Developing Drugs
Open Access

Vikash Kumar

Publications

• Research Article
  Nano-Carrier for Accentuated Transdermal Drug Delivery
  Author(s): Vidhi Malika, Kanchan Kohli, Hema Chaudhary and Vikash KumarVidhi Malika, Kanchan Kohli, Hema Chaudhary and Vikash Kumar
  
  This research objective was to design a nano-carrier for Glibenclamide (GBD) by loading it in to nano-transfersomes to provide an accentuated transdermal drug delivery for Non-Insulin Dependent Diabetes Mellitus (NIDDM) The nanotransfersomes were prepared by sonication method and optimized using a statistically three-factor three-level Factorial Design (Box-Behnken design). A second order equation (polynomial) was originated and construct contour plots (2- D) for prediction the responses and characterized by various parameters (i.e. entrapment efficiency, vesicle shape & size, zeta potential, degree of deformability, permeation and skin irritation study). The skin permeation of optimized formulation (GNTs2) was found to be significantly higher (enhancement ratio is 10.44) than the drug in solution and also further confirmed by fluorescence microscopy using due i.e. Rhodamine B. He.. View More»
  DOI: 10.4172/2329-6631.1000121

  Abstract PDF

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