Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Takashi Sugita
2-522-1 Noshio, Kiyose, Tokyo 204-8588
Japan
Research Article
Relationships among the Genotypes of Malassezia Globosa Colonizing Patients with Atopic Dermatitis, the Clinical Severity of the Disease, and the Level of Specific IgE Antibodies
Author(s): Otomi Cho, Mami Saito, Ryoji Tsuboi, Hiroshi Kato, Akemi Nishikawa, Sanae Nakajima and Takashi SugitaOtomi Cho, Mami Saito, Ryoji Tsuboi, Hiroshi Kato, Akemi Nishikawa, Sanae Nakajima and Takashi Sugita
Background: Various types of microorganisms colonize the skin surface, and some such as the bacterium Staphylococcus aureus and fungus Malassezia, exacerbate the symptoms of atopic dermatitis. Malassezia-specific IgE antibodies are present in the sera of patients with atopic dermatitis and the level thereof correlates with the severity of the condition. Malassezia has many genotypes. In the present study, we explored the relationships among the genotypes of Malassezia species colonizing patients with atopic dermatitis, the clinical severity of the disease, and the level of specific IgE antibody.
Methods: Scale samples were obtained from head or neck lesions of 74 patients with atopic dermatitis and 40 healthy subjects. The intergenic spacer (IGS) 1 region of the rRNA genes of M. globosa (.. View More»
DOI:
10.4172/2155-9554.1000197