Journal of Osteoporosis and Physical Activity

Journal of Osteoporosis and Physical Activity
Open Access

ISSN: 2329-9509

+44 1478 350008

T R Jackson

T R Jackson

United Kingdom

  • Review Article
    The Urocortin System: A Novel Bone Regulatory Triad, Working In Opposition to RANKL/RANK/OPG
    Author(s): K M Lawrence, T R Jackson and P A TownsendK M Lawrence, T R Jackson and P A Townsend

    Bone is in a continual state of flux, with old bone being continually replaced by new. This bone turnover, or remodelling, needs to be highly regulated to prevent disorders associated with aberrant bone mass. This process is controlled principally by two cell types, osteoclasts and osteoblasts, which are responsible for bone resorption and deposition respectively. A crucial, well established regulatory mechanism involved in the control of these cells is the RANKL/RANK/ OPG pathway. With this, an osteoblast derived ligand, RANKL, binds to an osteoclastic receptor RANK, producing increased osteoclastogenesis and resorption. In contrast the Ucn system has only recently been found in bone cells, where an osteoblast and osteoclast derived ligand Ucn1, binds to an osteoclast derived receptor CRF-R2β, resulting in inhibition of osteoclastogenesis and resorption. Both systems possess a r.. View More»
    DOI: 10.4172/2329-9509.1000147

    Abstract PDF

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