Advanced Techniques in Biology & Medicine
Open Access
ISSN: 2379-1764
+44 1223 790975
ISSN: 2379-1764
+44 1223 790975
Soo Yong Kim
Republic of Korea
Research Article
Development of a 68Ga-Labeled Bombesin Analog for Gastrin-Releasing Peptide Receptor-Expressing Prostate Tumor Imaging
Author(s): Jae Cheong Lim, So Hee Dho, Eun Ha Cho, So Young Lee, Soo Yong Kim, Sung Hee Jung and Jong Choon KimJae Cheong Lim, So Hee Dho, Eun Ha Cho, So Young Lee, Soo Yong Kim, Sung Hee Jung and Jong Choon Kim
Our previous study demonstrated the therapeutic efficacy of 177Lu-DOTA-gluBBN for the treatment of GRPRexpressing prostate tumors. As a matched pair for 177Lu, the development of labeling and molecular imaging technology using 68Ga is needed to introduce the “theranostic” approach. Therefore, the present study described the 68Ga-labeled bombesin analog, 68Ga-DOTA-gluBBN for the imaging of GRPR-expressing prostate tumors.
Methods: 68Ga was concentrated and labeled with DOTA-gluBBN using the NaCl method, and the labeling yield was evaluated by iTLC-SG. Human prostate PC-3 tumor cells were used to induce a subcutaneously xenografted-tumor model and a peritoneal metastasized tumor model. PET-CT imaging studies were performed in both animal models.
Results: Eluted 68Ga solution containing 5~10% of impurities.. View More»
DOI:
10.4172/2379-1764.1000135