Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Skroza N
Dermatology Unit “Daniele Innocenzi”,
Sapienza University of Rome, Fiorini Hospital ,Via Firenze snc Polo Pontino, 04019 Terracina
Italy
Short Communication
Psoriasis and Inflammatory Bowel Diseases: Epidemiological, Genetic and Pathogenetic Correlations: A Review of Literature
Author(s): Skroza N, Proietti I, La Viola G, Bernardini N, Aquila E and Potenza CSkroza N, Proietti I, La Viola G, Bernardini N, Aquila E and Potenza C
Inflammatory bowel diseases (IBDs) and psoriasis represent two chronic relapsing inflammatory disorders respectively of the gastrointestinal tract and of the skin. The relationship between IBDs and psoriasis has been observed only through epidemiological studies, however starting from 1990s genetic and immunological aspects have been studied in detail. Both conditions share a strong genetic correlation that involves the chromosomal loci 6p22, 16q, 1p31 and 5q33. Polymorphisms of these susceptibility loci are related to the alteration of immune mechanisms in both psoriasis and IBD. Cytokines such as IL-17A, IL-22, TGFβ, IL-6, IL-21 and IL-23 influence the activity of T-Helper 17 Cells (Th17) and T-Regulatory Cells (T-Regs), playing a key role into the inflammatory process and tissue damage. The comparable common course of psoriasis and IBD explains systemic implication seen in bot.. View More»
DOI:
10.4172/2155-9554.1000335