Journal of Cell Signaling
Open Access
ISSN: 2576-1471
+44 1223 790975
ISSN: 2576-1471
+44 1223 790975
Razieh Yazdanparast
Institute of Biochemistry and Biophysics,
Tehran
West Indies
Research Article
Manipulation of Cellular Redox State was Essential for Triggering Erythroid Differentiation of K562 Cells by Mycophenolic Acid
Author(s): Elahe Mirzarazi and Razieh YazdanparastElahe Mirzarazi and Razieh Yazdanparast
Reactive Oxygen Species (ROS) play important roles in a variety of normal cellular functions and various pathological events. Uncontrolled ROS production in various types of cancer cells has been globally reported and considered as a hallmark for new drug developments. Accordingly, in this study, we planned to investigate the probable roles of oxidants on erythroid differentiation of K562 cells under the influence of Mycophenolic acid (MPA).
Based on our results, MPA attenuated the intracellular SOD activity to provide a suitable redox environment for hemoglobinization of the exposed cells, while the cellular content of glutathione and glutathione peroxidase were augmented at the initial times of MPA-induced erythroid differentiation. These variations were accompanied by the significant reduction in the cellular ROS content in the first 8 h of MPA exposure followed by an eno.. View More»
DOI:
10.4172/2576-1471.1000151