Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
ISSN: 2329-6488
Paula C Bianchi
Brazil
Research Article
Exposure to Nicotine in Adult, but not Adolescent, Rats Increases Alcohol Self-Administration in Adulthood
Author(s): Paula C Bianchi, Fabio C Cruz, Paulo E Carneiro-de-Oliveira, Tarciso T Miguel, Marcelo T Marin, Ricardo L Nunez-de-Souza, Cleopatra S Planeta, Rodrigo M LeãoPaula C Bianchi, Fabio C Cruz, Paulo E Carneiro-de-Oliveira, Tarciso T Miguel, Marcelo T Marin, Ricardo L Nunez-de-Souza, Cleopatra S Planeta, Rodrigo M Leão
Among drugs of abuse, nicotine and alcohol are the most consumed in the world, and are often co-abused. Evidence has shown that nicotine enhances the consumption and subjective effects of ethanol. How nicotine increases alcohol consumption is an interesting question that is still left unanswered. We assessed whether repeated treatment with nicotine during adolescence or adulthood could increase operant alcohol selfadministration. Male adolescent and adult rats (postnatal day [PND] 28 and 60, respectively) were injected with nicotine (1.0 mg/kg, subcutaneously [s.c.], three times a day for 10 days). During this period, the control group received saline injections (0.1 ml/kg; s.c). On PND 72, adolescent and adult rats pretreated with nicotine were subjected to ethanol self-administration procedures. Alcohol oral self-administration patterns were evaluated using a progressive ratio sched.. View More»
DOI:
10.4172/2329-6488.1000280