Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 20 3868 9735
ISSN: 2155-9554
+44 20 3868 9735
Paula Aguilera
Dermatology Department. Melanoma Unit, Hospital Clínic,
IDIBAPS, Villarroel 170, 08036. Barcelona
Spain
Research Article
Clinical and Histopathological Characteristics between Familial and Sporadic Melanoma in Barcelona, Spain
Author(s): Paula Aguilera, Josep Malvehy, Cristina Carrera, Josep Palou, Joan Anton Puig-Butillé, Llúcia Alòs, Celia Badenas and Susana PuigPaula Aguilera, Josep Malvehy, Cristina Carrera, Josep Palou, Joan Anton Puig-Butillé, Llúcia Alòs, Celia Badenas and Susana Puig
Background: About 6 to 14% of melanoma cases occur in a familial setting. Germline mutations in CDKN2A are detected in 20 to 40% of melanoma families.
Objective: To characterise the clinical and histopathological characteristics of familial melanoma thus providing more information to clinicians and contribute to the understanding of the genetic-environment interplay in the pathogenesis of melanoma.
Methods: Clinical, histological and immunohistochemical characteristics of 62 familial melanomas were compared with 127 sporadic melanomas.
Results: variables associated with familial melanoma were earlier age at diagnosis (OR 1.036; 95% CI 1.017- 1.055), lower Breslow thickness (OR 1.2.. Read More»
DOI:
10.4172/2155-9554.1000231
