Journal of Alcoholism & Drug Dependence
Open Access

Palash Mandal

Publications

• Research Article
  Potential Molecular Mechanism of Probiotics in Alcoholic Liver Disease
  Author(s): Dhara Patel, Farhin Patel and Palash MandalDhara Patel, Farhin Patel and Palash Mandal
  
  Alcohol consumption and its abuse are significant prevalent cause for liver diseases and death worldwide. Increased bacterial endotoxin in the portal circulation, the plasma ratio of liver enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride implies the symbiotic relation between the gut and liver plays a key function in alcoholic liver disease (ALD). Consumption of alcohol leads to gut dysbiosis and informalities of the intestinal barrier, hyper gut permeability, oxidative stress, inflammation and adversely affect adipose tissue metabolism, and those are mainly recognized as major factors for progression of alcoholic liver disease. Alteration of gut microbiota is referred to as bacterial overgrowth which leads to the release of bacterial products to change in commercial/pathogenic microbiota equilibrium. Lipopolysaccharide (LPS) derived infla.. View More»
  DOI: 10.4172/2329-6488.1000278

  Abstract PDF

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