Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Olga Martínez Sáez
Hospital Universitario Ramon y Cajal,
Spain
Case Report
Toxicoderma Secondary to 5-Fluorouracil: Differential Diagnosis of Paraneoplastic Pemphigus
Author(s): Olga Martínez Sáez, Eva Hermosa Zarza, Alfredo Carrato Mena and Reyes Ferreiro MonteagudoOlga Martínez Sáez, Eva Hermosa Zarza, Alfredo Carrato Mena and Reyes Ferreiro Monteagudo
We present the case of a patient undergoing chemotherapy with 5-Fluorouracil (5-FU), irinotecan and cetuximab, who presented polymorphous skin lesions with oral and genital mucosal involvement. The differential diagnosis included paraneoplastic pemphigus, a severe autoimmune disease associated with neoplasms. The histology can be variable with acantholysis or lichenoid dermatitis. The presence of circulating antibodies supports the diagnosis. In our case, the anatomopathological and immunological findings and the clinical improvement after the suspension of 5-FU confirmed that it was toxicoderma secondary to the latter.
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DOI:
10.4172/2155-9554.1000396