Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Nilofer Qureshi
Tanzania
Research Article
Pharmacokinetics and Bioavailability of Annatto δ-tocotrienol in Healthy Fed Subjects
Author(s): Asaf A Qureshi, Dilshad A Khan, Shahid Saleem, Neerupma Silswal, Anne M Trias, Barrie Tan and Nilofer QureshiAsaf A Qureshi, Dilshad A Khan, Shahid Saleem, Neerupma Silswal, Anne M Trias, Barrie Tan and Nilofer Qureshi
Background: Although, α-tocopherol is the most bioavailable form of vitamin E, but several animal and clinical studies have demonstrated tocotrienol bioavailability to various tissues. There are few reports on bioavailability of tocotrienols in humans. Most studies were carried out with mixtures of tocotrienols + tocopherols rather than pure tocotrienols. Moreover, dietary α-tocopherol interferes with the bioavailability of tocotrienols, and prevents absorption and delivery to organs and tissues.
Aim: Pharmacokinetics and bioavailability of annatto-based δ-tocotrienol, plasma levels of α-, β-, γ-, δ-tocotrienol and tocopherols were quantified. In addition, several cytokines and microRNAs were examined.
Study design: An open-label, randomized study evaluated pharmacokinetics .. View More»
DOI:
10.4172/2155-9880.1000411