Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Ngugi M Piero
School of Pure and Applied Sciences,
P.O. Box 43844-00100, Nairobi
Kenya
Research Article
Antidiabetic and Safety of Lantana rhodesiensis in Alloxan Induced Diabetic Rats
Author(s): Ngugi M Piero, Kimuni NS, Ngeranwa NJ, Orinda OG, Njagi MJ, Maina D, Agyirifo SD, Gathumbi K, King’e WS and Njagi Eliud ENNgugi M Piero, Kimuni NS, Ngeranwa NJ, Orinda OG, Njagi MJ, Maina D, Agyirifo SD, Gathumbi K, King’e WS and Njagi Eliud EN
Lantana rhodesiensis Linn is used traditionally in the management of several diseases including diabetes mellitus; however, its efficacy and safety is not scientifically evaluated. The aim of this study was to determine in vivo hypoglycemic activity and safety of aqueous extracts of L. rhodesiensis in white male albino rats. Aqueous extracts were screened for their hypoglycemic activity in alloxan induced diabetic rats using the oral and intraperitoneal routes. The safety of these extracts was studied in rats orally or intraperitoneally administered with 1 g/kg body weight daily for 28 days by recording the changes in body and organ weight, hematological and biochemical parameters and histology. Mineral compositions of the extracts were estimated using total reflection X-Ray Fluorescence System (TRXF) while the types of phytochemicals present were assessed using standard procedures. A.. View More»
DOI:
10.4172/2329-6631.1000129