Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
+44 1223 790975
ISSN: 2329-6488
+44 1223 790975
NA Bokhan
Serbia
Research Article
Original Anticonvulsant Urea Derivative Alters the Properties of Benzodiazepine Receptors “Central” and “Peripheral” Types in the Cerebral Cortex of “Heavy Drinkers” Rats.
Author(s): TV Shushpanova, AV Solonskii, NA Bokhan, TP Novozheeva, VV Udut, GA Arbit and VD FilimonovTV Shushpanova, AV Solonskii, NA Bokhan, TP Novozheeva, VV Udut, GA Arbit and VD Filimonov
Objective: studies of anticonvulsants have a stimulating effect on neuronal receptors; in particular GABAA/ benzodiazepine receptor complex (GABAA/BzDR) can be the basis for the development of new approaches to the treatment of alcohol withdrawal syndrome (AWS) and alcohol addiction. Benzodiazepine receptors (BzDRs) of the cerebral cortex of Wistar male rats with a different preference for alcohol and BzDRs in the brain “heavy drinkers” rats, treated with original anticonvulsant meta-chloro-benzhydryl urea (m-ch-BHU) were examined in these study.
Materials and methods: Wistar male rats (n=250) were used in an experimental model of alcoholism. Properties of the BzDRs of the “central” (synaptic) and “peripheral” (mitochondrial) type were exa.. View More»
DOI:
10.4172/2329-6488.1000234