Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
MV Romano
Department of Clinical and Molecular Biomedicine,
Catania
Italy
Case Report
Itching Skin Rash during Valproic Acid Therapy in Co-Administration with Silodosin: a Case Report and Review of Literature
Author(s): MV Romano, M Marino, M Cinconze, MR Nasca, R Furnari, A Petralia and MS SignorelliMV Romano, M Marino, M Cinconze, MR Nasca, R Furnari, A Petralia and MS Signorelli
Valproic acid (VA) is an antiepileptic drug commonly used in psychiatric setting as mood stabilizer. It is generally well-tolerated but, because of its pharmacodynamic properties, it may cause different adverse drug reactions, especially when it is co-administrated with other drugs.
Here we report the case of a 65 year old man with a Bipolar Disorder type I, according to DSM V, hospitalized for a depressive relapse and treated with Valproic Acid 300 mg/day, Lorazepam 2.5 mg/day, and Elopram 40 mg/ml intravenous daily infusions. When, one week after admission, Silodosin 8 mg/day was added for the management of Benign Prostatic Hyperplasia (BPH) symptoms, he developed an extensive pruritic and purpuric skin rash on his lower legs that subsided after valproic acid discontinuation and therapy with intravenous fluids and oral antihistamines. Therefore, valproic acid was replaced .. View More»
DOI:
10.4172/2155-9554.1000339