Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Menezes FC
Sao Paulo, 255 Doctor Eneias de Carvalho Aguiar Avenue, 3rd Floor, SP
Brazil
Research Article
Potential of Migration and Tissue Reactions to Intraperitoneally Implanted Polymethyl Methacrylate in Wistar Rats
Author(s): Menezes FC, Luna ACL and Diogo Filho AMenezes FC, Luna ACL and Diogo Filho A
Objective: This study aimed to evaluate the performance of polymethyl methacrylate (PMMA) when implanted into the peritoneal cavities of Wistar rats, specifically its potential for migration to the examined organs and possible tissue reactions at the implantation site.
Methods: Adult male Wistar rats (290-400 g) were distributed randomly into 2 groups: P4 (n=20), to which 0.4 mL of PMMA was administered; and P2 (n= 0), to which was 2 mL of PMMA were administered. These groups were subsequently divided into 4 subgroups according to the day on which euthanasia occurred (day 1, 7, 14, or 28).
Results: The changes in animal weight prior to PMMA implantation and after euthanasia were compared. No nodules or signs of PMMA implantation or any other macroscopic alterations were observed in the spleen, kidneys, lungs, or liver. H.. View More»
DOI:
10.4172/2155-9554.1000377