Journal of Clinical & Experimental Dermatology Research
Open Access

Mayur M Amonkar

Publications

• Research Article
  Systematic Review and Indirect Treatment Comparison of Dabrafenib and Trametinib versus Other Treatments Used in Previously Untreated Metastatic Melanoma Patients
  Author(s): Kunal Srivastava, Mayur M Amonkar, Amit Ahuja, Ceilidh Stapelkamp, Suzanne Swann, Michelle Casey and Cheena RanaKunal Srivastava, Mayur M Amonkar, Amit Ahuja, Ceilidh Stapelkamp, Suzanne Swann, Michelle Casey and Cheena Rana
  
  Objectives: A systematic literature review was undertaken with quantitative analysis, including meta-analysis and Bucher-adjusted indirect treatment comparisons (ITCs), to evaluate efficacy, safety, and tolerability of dabrafenib and trametinib monotherapy versus other first-line metastatic melanoma (MM) treatments. Methods: Embase®, MEDLINE®, CCTR, and key conferences were searched through October 2012 for relevant randomized controlled trials. Using a random-effects network meta-analysis, dabrafenib and trametinib were compared directly versus dacarbazine (DTIC) and indirectly versus ipilimumab plus DTIC, temozolomide, and vemurafenib. A Rank Preserving Structural Failure Time Method was used to adjust overall survival (OS) estimates in studies that allowed treatment crossover upon progression. .. View More»
  DOI: 10.4172/2155-9554.10000294

  Abstract PDF

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