Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Makoto Mizuno
KOSÉ Corporation,
1-18-4 Azusawa, Itabashi-ku, Tokyo 174-0051
Japan
Letter
In vitro Evaluation of the Skin Sensitizing Potential of Chemical Peeling Agents by the Human Cell Line Activation Test
Author(s): Makoto Mizuno, Hajime Asano, Koichi Kameyama, Fukumi Furukawa and Yuki YamamotoMakoto Mizuno, Hajime Asano, Koichi Kameyama, Fukumi Furukawa and Yuki Yamamoto
Chemical peeling results in a defect in the epidermal and dermal barrier. Therefore there is a possibility that chemical peeling may increase the risk for allergic contact dermatitis. In particular, from the viewpoint of allergic contact dermatitis, one should be cautious of peeling agents which destruct the epidermal and dermal barrier, penetrate deeply into the skin and increase the opportunity to interact directly with antigen presenting cells. However, to our knowledge, experimental trials on the skin sensitizing properties of peeling agents as a group have not been reported yet. In this study, we evaluated the skin sensitizing properties of five peeling agents, lactic acid, glycolic acid, trichloroacetic acid, salicylic acid and phenol, using the Human Cell Line Activation Test (h-CLAT), which is an in vitro test method. Lactic acid and glycolic acid were judged to be &#.. View More»
DOI:
10.4172/2155-9554.1000191