Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Mahendra MHR
Sri Lanka
Research Article
Superantigen Profile of Staphylococcus Aureus Isolates from Patients with Atopic Dermatitis in Sri Lanka
Author(s): Gomes PLR, Gathsaurie Neelika Malavige, Fernando N, Mahendra MHR, Seneviratne JKK and Graham S OggGomes PLR, Gathsaurie Neelika Malavige, Fernando N, Mahendra MHR, Seneviratne JKK and Graham S Ogg
Background:Staphylococcus aureus colonizes most patients with atopic dermatitis. Staphylococcus aureus is able to produce staphylococcal enterotoxins, staphylococcal enterotoxin-like toxins and Toxic shock syndrome toxin – 1.The presence of superantigen encoding genes has been associated with atopic dermatitis in other cohorts.
Aim: To determine the association of different Staphylococcal superantigens with clinical disease severity in a tropical disease setting in patients with atopic dermatitis.
Methodology: Skin swabs collected from 100 patients with atopic dermatitis and 120 controls were cultured. Severity of atopic dermatitis was graded using the Nottingham Eczema Severity Score. Bacterial DNA was extracted and superantigen genes were detected by separate PCRs.
Results:52/59 (.. View More»
DOI:
10.4172/2155-9554.1000136