Journal of Cell Signaling
Open Access
ISSN: 2576-1471
ISSN: 2576-1471
M Cristina Castañeda-Patlán
Mexico
Review Article
The Role of Hypoxia-Inducible Factors in Cancer Resistance
Author(s): Abril Saint-Martin, M Cristina Castañeda-Patlán and Martha Robles-Flores*
Abril Saint-Martin, M Cristina Castañeda-Patlán and Martha Robles-Flores*
Diminished oxygen availability (hypoxia) is a hallmark of the tumor microenvironment. A major regulator of cellular adaptation to hypoxia is the hypoxia-inducible factor (HIF) family of transcription factors, which play key roles in many crucial aspects of cancer biology including angiogenesis, stem cell maintenance, metabolic reprogramming, resistance to apoptosis, autocrine growth factor signaling, the EMT program, invasion and metastasis.
Resistance to chemotherapy/radiotherapy is the primary cause for treatment failure in clinical oncology. Hypoxia and accumulation of hypoxia-inducible factors (HIFs) in solid tumors have been associated with resistance to treatment and poor prognosis. HIFs causes autophagy establishment to promote survival of cancer cells, and is also associated with the promotion and maintenance of cancer stem cells, a minority subpopulation within the .. View More»
DOI:
10.4172/2576-1471.1000154