Journal of Cell Signaling

Journal of Cell Signaling
Open Access

ISSN: 2576-1471

Liting Sun

  • Commentary
    Different Manners of Interplay between MicroRNAs and Gene Programs in Neuronal Specification
    Author(s): Liting Sun, Yang Liu and Changgeng PengLiting Sun, Yang Liu and Changgeng Peng

    MicroRNA (miRNA) plays a critical role in self-renewal and differentiation of neural stem cells as well as proliferation and specification of neuronal progenitors through regulating spatial and/or temporal expression of its targets. It’s well documented that mutually exclusive or opposing gradient expression pattern of miRNA and its target gene diversifies subtypes of neurons and even specifies distinct functional properties of bilaterally symmetric neurons. Unlike these mechanisms, we recently showed that miR-183-96-182 cluster timely differently shuts off co-expressed transcription factor SHOX2 in the progenitor pool to generate two subtypes of low threshold mechanoreceptor (LTMR) neurons, early close of SHOX2 expression promoting the fate of Aβ slowly adapting (SA) LTMR neurons and late off leading to the identity of Aδ LTMR neurons. It indicates that population si.. Read More»
    DOI: 10.4172/2576-1471.1000193

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