Journal of Infectious Diseases & Preventive Medicine
Open Access

Lauren Togonon Arayan

Publications

• Research Article
  A Microarray-Based Analysis of Differentially Expressed Genes in Intracellular Brucella abortus 544 within Mdbk Cells
  Author(s): Huynh Tan Hop, Alisha Wehdnesday Bernardo Reyes, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Son Hai Vu, Wongi Min, Hu Jang Lee and Suk Kim Huynh Tan Hop, Alisha Wehdnesday Bernardo Reyes, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Son Hai Vu, Wongi Min, Hu Jang Lee and Suk Kim
  
  Background: Modulation of gene expression is a fundamental requirement for adaptation of intracellular Brucella abortus. Since most of the current understanding mainly focus on professional phagocytes and renal involvement is uncommon in brucellosis, our aim was to identify and analyze changes in B. abortus gene expression in response to intracellular environment within a bovine kidney cell line. Methodology: B. abortus RNA were isolated from Madin-Darby bovine kidney (MDBK) epithelial cells during replicative phase and the transcriptional profile of intracellular B. abortus was characterized using microarray analysis. Results and interpretation: The microarray analysis revealed a total of 1,623 differentially expressed genes of ≥ 2-fold–788 (25.44%, 788/3098) upregulated and 835 (26.9.. View More»
  DOI: 10.4172/2329-8731.1000181

  Abstract PDF

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