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Journal of Clinical & Experimental Dermatology Research

Journal of Clinical & Experimental Dermatology Research
Open Access

ISSN: 2155-9554

+44 1478 350008

Kõks S

Kõks S

Estonia

Publications
  • Research Article
    Possible Role of Endoplasmatic Reticulum Stress in Psoriasis Vulgaris
    Author(s): Prans E, Kingo K, Traks T, Mössner R, Silm H and Kõks SPrans E, Kingo K, Traks T, Mössner R, Silm H and Kõks S

    Plaque psoriasis is a chronic immune-mediated inflammatory skin disease. The role of cytokines in the development of psoriasis is well known and has been studied for decades. Endoplasmic reticulum (ER) stress is the cellular response to the disturbed homeostasis in the ER. ER stress is involved in different human pathologies, including chronic inflammatory and degenerative conditions. The aim of our study was to explore whether the single nucleotide polymorphisms (SNPs) in ER stress related genes are associated with a higher risk for plaque psoriasis. We studied 29 SNPs in the following ER stress genes: ATF6 (chr1), HSPA5 (chr9), HSP90B1 (chr12), ERN1 (chr17), XBP1 (chr22). Single marker analysis resulted in significant associations with the HSP90B1 gene (rs17034977, p=0.0232) and with the ERN1 gene (rs9916168, p<0.0001.. View More»
    DOI: 10.4172/2155-9554.1000419

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