Journal of Clinical & Experimental Dermatology Research
Open Access

Koichi Ishida

Publications

• Review Article
  Role of Ceramide in the Barrier Function of the Stratum Corneum, Implications for the Pathogenesis of Atopic Dermatitis
  Author(s): Genji Imokawa and Koichi IshidaGenji Imokawa and Koichi Ishida
  
  Atopic dermatitis is a recurrent dermatitis which is characterized clinically by atopic dry skin and functionally by cutaneous barrier disruption even in the non-lesional skin. These abnormalities have been thought to be mainly attributable to significantly decreased levels of ceramides even in the non-lesional stratum corneum. Recently, in association with the barrier disruption in atopic dermatitis skin, prevalent and rare loss-of-function mutations in the gene encoding filaggrin have been reported to be an important pre-disposing factor for the development of atopic dermatitis. However, a mechanistic connection between filaggrin loss-of-function mutations and barrier disruption has not been resolved and remains controversial. This review article explores the physiological and biochemical basis for the atopic dermatitis phenotype in terms of the barrier .. View More»
  DOI: 10.4172/2155-9554.1000206

  Abstract PDF

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