Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Kobayashi H
Shizuoka Cancer Center,
1007 Shimonagakubo, Nagaizumi-cho Sunto-gun, Shizuoka 411-8777
Japan
Research Article
Effect of Second-Line Chemotherapy in Elderly Patients with Non-Small Cell
Lung Cancer
Author(s): Kobayashi H, Kenmotsu H, Suzuki K, Omori S, Nakashima K, Wakuda K, Ono A, Naito T, Murakami H, Endo M, OhdeY and Takahashi TKobayashi H, Kenmotsu H, Suzuki K, Omori S, Nakashima K, Wakuda K, Ono A, Naito T, Murakami H, Endo M, OhdeY and Takahashi T
Background: The effect of second-line chemotherapy in patients with non-small cell lung cancer (NSCLC) who received first-line chemotherapy at the age of ≥ 75 years is unclear.
Methods: Sixty-five elderly patients with NSCLC who received first-line chemotherapy at the age of ≥ 75 years and treated with second-line chemotherapy at Shizuoka Cancer Center between January 2005 and December 2014 were retrospectively reviewed.
Results: The overall response rate of the second-line chemotherapy was 9.2% [95% confidence interval (CI) 4-19]. The median progression-free survival at the second-line chemotherapy was 2.2 months. The median overall survival at the second-line chemotherapy was 7.5 months. Multivariate analysis of prognostic factors showed that an Eastern Cooperative Oncology Group performance-status score (P.. View More»
DOI:
10.4172/2167-7700.1000236